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William McArthur and Jeffrey Williams were spending the night in the station's Quest airlock in conditions of lower air pressure to test a new routine for preparing the body for a spacewalk. To prevent nitrogen bubbles from entering the bloodstream and causing painful decompression sickness, nitrogen needs to be expelled from the body before astronauts venture into space in their low-pressure space suits.

Usually, crew members breathe pure oxygen to purge the body of nitrogen. But spending time in a low-pressure environment may speed up the process from hours to minutes. So the two astronauts camped out in the closet-sized airlock on Monday and lowered its pressure from 14.7 pounds per square inch (psi) to 10.2 psi to test how well the airlock maintained its pressure and oxygen levels.